Marguerite is a native Philadelphian. Following her marriage to H. F. (Gerry) Lenfest they lived in New York where Marguerite taught elementary school. Marguerite and Gerry purchased two cable TV systems from Walter Annenberg and became partners in what later became Lenfest Communications. After twenty-five years Lenfest Communications was sold to Comcast in 2000.

Marguerite’s grandfather, James Randolph Fisher, graduated from PAFA in 1891. Marguerite serves on four foundations, two art museums, and one college Board.